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KMID : 0545120150250101697
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Journal of Microbiology and Biotechnology
2015 Volume.25 No. 10 p.1697 ~ p.1701
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Anticancer and Anti-Inflammatory Activity of Probiotic Lactococcus lactis NK34
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Han Kyoung-Jun
Lee Na-Kyoung
Park Hoon
Paik Hyun-Dong
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Abstract
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The anticancer and anti-inflammatory activities of probiotic Lactococcus lactis NK34 were demonstrated. Treatment of cancer cells such as SK-MES-1, DLD-1, HT-29, LoVo, AGS, and MCF-7 cells with 106 CFU/well of L. lactis NK34 resulted in strong inhibition of proliferation (>77% cytotoxicity, p < 0.05). The anti-inflammatory activity of L. lactis NK34 was also demonstrated in lipopolysaccharide-induced RAW 264.7 cells, where the production of nitric oxide and proinflammatory cytokines (tumor necrosis factor-α, interleukin-18, and cyclooxygenase-2) was reduced. These results suggest that L. lactis NK34 could be used as a probiotic microorganism to inhibit the proliferation of cancer cells and production of proinflammatory cytokines.
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KEYWORD
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Probiotic, Lactococcus lactis, anticancer activity, anti-inflammatory activity, cytokine
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